Who is miescher

Reimer, Berlin. Harris H The birth of the cell. Hershey AD, Chase M Independent functions of viral proteins and nucleic acid in growth of bacteriophage.

J Gen Physiol — His W a Aus dem wissenschaftlichen Briefwechsel von F. Vogel, Leipzig, pp 33— Vogel, Leipzig. His W d Einleitung. Vogel, Leipzig, pp 1—4. His W e F. Vogel, Leipzig, pp 5— August Hirschwald, Berlin.

Medicinisch-chemische Untersuchungen — Kiernan JA Histological and histochemical methods—theory and practice. Arnold, London. Klose A Viktor von Bruns und die sterile Verbandswatte.

Kossel A Ueber die chemische Zusammensetzung der Zelle. Kossel A The chemical composition of the cell nucleus; nobel lecture, 12th December Nobel Lectures, Physiology or Medicine — Kossel A Beziehungen der Chemie zur Physiologie. Teubner, Leipzig, pp — Engelmann, Leipzig, pp 49— Lagerkvist U DNA pioneers and their legacy. Frankfurt am Main. Lister J On the antiseptic principle of the practice of surgery.

Lancet —, — Miescher, vol 1. Vogel, Leipzig, p Vogel, Leipzig, pp 39— Vogel, Leipzig, pp 58— Vogel, Leipzig, pp Arbeiten von F. Miescher, vol 2. Vogel, Leipzig, pp 32— Vogel, Leipzig, pp 63— Miescher F c Ueber die chemische Zusammensetzung der Eiterzellen. Vogel, Leipzig, pp 44— Vogel, Leipzig, pp 64— Vogel, Leipzig, pp 68— Boehm; Basel, May 2nd, Vogel, Leipzig, pp 70— Berichte der deutschen chemischen Gesellschaft VII Miescher F b Die Spermatozoen einiger Wirbeltiere.

Ein Beitrag zur Histochemie. Verhandlungen der naturforschenden Gesellschaft in Basel VI— Vogel, Leipzig, pp 76— However, during these experiments, he noticed a substance with unexpected properties that did not match those of proteins. Miescher had obtained the first crude purification of DNA. He further examined the properties and composition of this enigmatic substance and showed that it fundamentally differed from proteins. He experimented and isolated a new molecule - nuclein - from the cell nucleus.

He determined that nuclein was made up of hydrogen, oxygen, nitrogen and phosphorus and there was an unique ratio of phosphorus to nitrogen. He was able to isolate nuclein from other cells and later used salmon sperm as opposed to pus as a source.

Although Miescher did most of his work in , his paper on nuclein wasn't published until Nuclein was such a unique molecule that Hoppe-Seyler was skeptical and wanted to confirm Miescher's results before publication. Miescher continued to work on nuclein for the rest of his career. He also examined the metabolic changes that occur in salmon when they spawn. In , Miescher was appointed the professor of physiology at the University of Basel , a position previously held by his father and then his uncle.

The appointment meant more funds and equipment for research, but it also meant that Miescher had to teach. Although he put in a lot of time and effort, Miescher was not a good teacher. His shyness and preoccupation with his research made it difficult for him to relate to his students. He was a perfectionist and a workaholic, and often worked very long hours to do the nuclein isolations.

It would be years before the role of nucleic acids were recognized. Miescher, himself, believed that proteins were the molecules of heredity. However, Miescher laid the groundwork for the molecular discoveries that followed. Miescher died in from tuberculosis. Phoebus Levene knew Ivan Pavlov — the physiologist who developed the idea of the conditional reflex by training dogs to salivate at the sound of a bell.